Tesofensine, a serotonin-noradrenaline-dopamine reuptake inhibitor, is a novel compound with a massive impact on weight loss. The compound works by suppressing appetite and enhancing resting energy expenditure. 

Apoxar is one of the very few early adopters of the formula in Canada. Most information the community has about Tesofensine is based on successful studies and trials, so it’s potentially a future big thing that hasn’t gained its popularity yet.

How Tesofensine Works

Tesofensine influences the availability of serotonin, noradrenaline, and dopamine in the brain by inhibiting neurotransmitters associated with hunger and appetite. 

Initially explored for its effects on Parkinson’s and Alzheimer's, its impact on weight reduction shifted its research focus towards treating obesity. 

The compound stimulates the cholinergic system indirectly and has demonstrated superior efficacy compared to other weight loss agents.

Benefits

Tesofensine has a combination of effects, but it’s primarily used as a weight loss agent. The trial groups that were administering tesofensine showed a significant reduction in body fat, with 6-month usage revealing a notable decline in weight and improvements in body composition metrics like BMI.

At the same time, its neuroprotective qualities showcase positive effects on cognition, particularly improving learning and memory capabilities.

Full list of tesofensine benefits includes:

• Significant weight loss;
• Appetite suppression;
• Increased metabolism;
• Fat reduction;
• Waist and hip circumference reduction;
• BMI reduction;
• Neuroprotective properties;
• Enhanced cognition;
• Antidepressant potential;
• Improved insulin sensitivity;
• Elevated energy expenditure;
• Enhanced fat oxidation;
• Improved body composition;
• Cognitive decline mitigation;
• Enhanced learning capabilities;
• Improved memory.

Side Effects

Insomnia, nausea, and diarrhea are the most frequent side effects, with an increased blood pressure observed particularly at higher dosages. 

Several trials unfolded other side effects, including:

• Dry mouth;
• Tachycardia;
• Constipation;
• Fluctuations in heart rate. 

Hypertension concerns have positioned the medium dose in a favorable light amongst researchers, simply because it can promote significant weight loss without cardiovascular complications. 

Tesofensine Dosage and Cycle

In a study conducted over 34 weeks, participants used Tesofensine alongside a classic diet. The recorded mean weight loss exceeded the effects of diet and placebo:

• 4.5% for a dosage of 0.25 mg;
• 9.2% for 0.5 mg;
• and 10.6% for 1 mg. 

The Tesofensine group also recorded approximately 10 times higher instances of losing 10 kg or more of initial body weight in comparison to the placebo group.

We suggest that a daily dose of tesofensine 0.5 mg, administered for 6 months, is the right way to go. Starting at 0,25 mg ED might be a good way to see how the body responds to the compound with minimal risks.'