Cabergoline, a dopamine agonist medication, is an FDA-approved cornerstone in the management of conditions associated with elevated prolactin levels, such as hyperprolactinemia and prolactinomas.

Mechanism of Action

Cabergoline acts as a dopamine receptor agonist, specifically targeting D2 receptors in the pituitary gland. In simple terms, it inhibits the secretion of prolactin, a hormone responsible for lactation and regulation of the menstrual cycle.

Also, Cabergoline has been shown to exert direct inhibitory effects on prolactinoma cells, leading to tumor shrinkage and normalization of prolactin levels.

Indications: When Do You Need Cabergoline

In short — you need it with Trenbolone, NPP and Deca Durabolin. These are the two (since NPP is just a faster Deca, essentially) steroids are the worst in terms of high prolactin risks, so you need Caber to manage the effects. 

Officially, Cabergoline is indicated for the treatment of hyperprolactinemia, a condition characterized by elevated levels of prolactin in the blood. Also, it serves as a first-line therapy for prolactinomas. Long-term Cabergoline therapy may be required to maintain hormonal balance and prevent tumor recurrence.

Dosage and Administration

The recommended dosage of Cabergoline typically ranges from 0.25 to 1 milligram per week, administered orally and divided into one or two doses.

The starting dose is usually low, with gradual climb upwards, based on individual response and tolerability. Regular blood work and monitoring of prolactin levels is essential to assess treatment efficacy and adjust the dosage as needed.

Cabergoline is generally well-tolerated, but some individuals may experience side effects such as nausea, dizziness, headache, fatigue, and gastrointestinal disturbances. These effects are usually mild and transient, often resolving with continued use or dose adjustment. In rare cases, Cabergoline may be associated with more serious adverse reactions, including cardiac valve disorders and psychiatric symptoms such as hallucinations or compulsive behaviors.