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Apoxar Higenamine (Energy, Focus, Fat Loss) - 20mg/tab, 50tabs | Apoxar

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Quick Overview

Higenamine (Norcoclaurine) is part of the Nandina plant that has traditionally been used as an anti-asthmatic and is currently used as a fat burner due to sharing similar mechanisms to ephedrine;


What is Higenamine

Higenamine is a weight-loss agent with a potential to boost energy, with some people also reporting benefits related to enhanced mental clarity and appetite suppression. 

This molecule, found in certain plants like sacred bamboo, functions as a β2 agonist, sharing similarities in mechanism to Clenbuterol. 

However, it has a rapid onset and short duration in the human body, being metabolized quickly with peak blood levels at 10 minutes post-ingestion.

How does Higenamine work?

Higenamine promotes fat burning primarily through its interaction with beta-adrenergic receptors, specifically the β2 subtype:

  1. Higenamine binds to β2-adrenergic receptors on fat cells;
  2. This binding activates a cascade of intracellular events;
  3. The key event is the activation of adenylate cyclase, an enzyme that increases the production of cyclic adenosine monophosphate (cAMP);
  4. Elevated cAMP levels activate protein kinase A (PKA);
  5. PKA subsequently activates hormone-sensitive lipase (HSL);
  6. HSL begins the process of lipolysis, breaking down triglycerides stored in fat cells into glycerol and free fatty acids.

Higenamine may also increase basal metabolic rate (BMR) due to its thermogenic effects and its ability to increase overall energy expenditure. The freed fatty acids can then be utilized as an energy source.

At the same time, by acting as a bronchodilator, higenamine can enhance oxygen availability, further supporting fat utilization and energy production.


The benefits of higenamine are based on its pharmacological actions and anecdotal reports. Higenamine is not a magic bullet and should not be taken lightly. 

With cautious and responsible approach, you can expect:

  • Increased metabolic rate;
  • Enhanced lipolysis;
  • Appetite suppression;
  • Improved performance;
  • Improved mental clarity;
  • Elevated fatty acid oxidation;
  • Short-term energy boosts;
  • Increased thermogenesis;
  • Elevated peak power output.

Side Effects

Higenamine side effects can depend on the dosage, individual susceptibility, and the duration of use. Not everyone is guaranteed to experience these side effects, but awareness and caution are still important: 

  • Increased heart rate;
  • Elevated blood pressure;
  • Dizziness;
  • Chest congestion;
  • Dry mouth;
  • Anxiety or nervousness;
  • Sweating or excessive perspiration;
  • Shortness of breath;
  • Possible allergic reactions;
  • Headaches;
  • Nausea or vomiting.

How to Take Higenamine

  • Dosage: 20-30 mg per dose;
  • Frequency: 2-3 times daily;
  • Cycle Duration: Up to 3-4 weeks if using doses over 10 mg.

Given the rapid action and metabolism of Higenamine, it is recommended to divide the daily dose into multiple administrations.

Also, we recommend to follow these safety measures:

  • Ensure to have pauses between cycles and carry out frequent blood works to monitor physiological markers;
  • Go for a thorough heart health check-up, especially if considering stacking Higenamine with other substances;
  • Monitor side effects closely and cease use if any adverse reactions occur.

If pre-existing health conditions (especially heart or liver-related) are present, explore alternative fat-burning options.


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